One key sign not indicative of opioid overdose is pinpoint pupils. While constricted pupils are a common symptom, pinpoint pupils might not always be present. Other signs such as slow or shallow breathing, confusion, and unconsciousness are more reliable indicators. It’s crucial to recognize the broader spectrum of symptoms, as solely relying on pinpoint pupils may lead to a delayed response in identifying and addressing opioid overdoses. Comprehensive awareness of various signs ensures a more accurate and timely intervention in emergency situations.